For the drug treatment of functional dyspepsia, how to choose drugs for different groups of people and different symptoms?

Functional dyspepsia (FD) is a common functional gastrointestinal disease, which is a group of persistent or recurrent epigastric pain, epigastric burning sensation, postprandial fullness discomfort, early satiety, excessive belching, epigastric distension Gastrointestinal symptoms, such as gas and nausea, are the main manifestations, which can appear together with symptoms of gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS). Some of the onset and recurrence are related to mental and psychological factors and diet.
FD can be divided into postprandial discomfort syndrome (PDS), epigastric pain syndrome (EPS), etiology and gastrointestinal motility disorder, visceral hypersensitivity, abnormal gastric acid secretion, mucosal and immune function changes, Helicobacter pylori (Hp) Infection, changes in intestinal flora, mental and psychological factors, and abnormal regulation of the central nervous system.
This article summarizes the selection of drugs for the treatment of FD.
Drugs for the treatment of FD The
drugs for the treatment of FD mainly include antacids, prokinetic drugs, anti-Hp infection drugs, and anti-anxiety and depression drugs.
For the drug treatment of functional dyspepsia, how to choose drugs for different groups of people and different symptoms?
Drug selection for different populations
Antacids can be used for children with FD, including PPIs (such as omeprazole), H2 receptor antagonists (such as famotidine); antacids (such as aluminum magnesium carbonate); prokinetic drugs (such as domperidone, itopride); antihistamine cyproheptadine; anti-Hp infection drugs.
Elderly patients with FD can choose antacids, prokinetic drugs, anti-Hp infection drugs, anti-anxiety and depression drugs, and other therapeutic drugs such as antacids, gastric mucosal protective agents, digestive enzyme preparations, and probiotic preparations.
Drug selection for FD patients with different symptoms
Antacids (PPI, H2 receptor antagonists) and prokinetic drugs are the first-line treatment for FD.
The main symptom of Postprandial Discomfort Syndrome (PDS) is postprandial fullness or early satiety, which affects normal eating. The first-line treatment is mainly prokinetic drugs or combined with antacids.
The main symptom of epigastric pain syndrome (EPS) is epigastric pain or burning sensation, which can be induced or relieved by eating, and can also occur during fasting. The first-line treatment drugs are mainly PPI, H2 receptor antagonists, and antacids , Prokinetic drugs can be used in combination if necessary.